Carl Gustaf Saluste, Ph.D.
Department of Natural Sciences
Chemistry
Education
M.Sc., University of Lund, Sweden (1996)
Ph.D., University of Southampton, UK (2001)
Practice Areas
- Organic Chemistry (synthesis and methodology)
Publications and Media Placements
Saluste, C.G., Ortega M.A., Pastor, J. et al. 鈥淔ragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors. Plos One, 2012, 7, 1.
Mart铆nez, S., Hern谩ndez, A.I., Rodr铆guez, A., Saluste, C.G. et al. 鈥淚dentification of ETP-46321, a potent and orally bioavailable PI3Ka,d ,-inhibitor鈥�. Bioorg. Med. Chem. Lett. 2012, 22, 3460.
Pastor, J., Oyarzabal, J., Saluste, C.G. et al. 鈥淗it-to lead evaluation of 1,2,3-Triazolo [4,5-b] pyridines as PIM-kinase inhibitors鈥�. Bioorg. Med. Chem. Lett., 2012, 22, 1591.
Martin, M.W., Newcomb, J., Ghiron, C., Saluste, C.G. et al. 鈥淪tructure-based design of novel 2-amino-6-phenyl-pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR and in vivo anti-inflammatory activity鈥�. J. Med. Chem., 2008, 51, 1637.
Saluste, C.G., Crumpler, S., Furber, M., Whitby, R.J. 鈥淧alladium-catalysed synthesis of cyclic amidines and imidates鈥�. Tetrahedron Letters, 2004, 45, 6995.
Whitby, R.J., Saluste, C.G., Furber, M. 鈥淪ynthesis of a-iminoimidates by palladium-catalysed double isonitrile insertion鈥�. Org. Biomol. Chem., 2004, 2, 1974.
C.G. Saluste, C. Ghiron-Thomas, M. Ermann, P. Amouzeg and E. Power, Patent application with AMGEN Pharmaceuticals, July 2003.
C.G Saluste, R.J Whitby and M. Furber, 鈥淧alladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides鈥�, Tetrahedron Lett., 2001, 42, 6191.
C.G Saluste, R.J Whitby and M. Furber, 鈥淎 Palladium catalysed synthesis of amidines from aryl halides鈥�, Angew. Chem. Int. Ed. Engl., 2000, 89, 4156.
C.G. Saluste, U. Berg, N. Bladh, A. Hjelmencrantz and M. Stodeman 鈥淪tructure and Dynamic
Stability of Cyclodextrin Inclusion Complexes with 1,4-Disubstituted Bicyclo-[2.2.2]octanes鈥�.
Poster Presentation, 8th Meeting on Stereochemistry August 1998, Tepla, Czeck Republic.
Patents:
Nunes, J., Xiotian, Z., Saluste, C.G. et al. 鈥淪ubstituted Heterocycles and Methods of Use鈥�. WO/2005/021551.
Pastor, J., Garc铆a-Collazo, A.M., Saluste, C.G. et al. 鈥淭ricyclic Compounds for Use as Kinase Inhibitors鈥�. WO/2011/080510.
Pevarello, P., Garc铆a-Collazo, A.M., Saluste, C.G. et al. 鈥淚midazopyridazines for Use as Protein Kinase Inhibitors鈥�. US/2011/0046127.
Pastor, J., Oyarzabal, J., Saluste, C.G. et al. 鈥淭riazolo [4,5-b]pyridine derivatives鈥�. WO/2011/101644.
Stay as guest researcher:
05/2017-07/2017: CNIO, Madrid, Spain: Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Crosslinkers to be tested for incorporation to Kinase inhibitors.
01/2015-05/2015: Universidad Complutense, Madrid, Spain: Preparation of synthetic metabolites for pathogenic bacteria, part of the human bacteriotal.